Blue Lotus

The Blue Lotus flower has been part of Egypt’s mythology, culture, and medicine for thousands of years. In the Middle East, the plant is known as Egyptian Lotus and Sacred Lily of the Nile, and images of the aquatic plant grace the walls of pharaohs’ tombs and monoliths. The history of the famed Blue Lotus is not only medicinal, but also mystical, in nature. Finding its way out of Egypt, around 300 BCE, the lotus landed in Greece, where the prevailing culture incorporated it into the religion of Isis and Serapis. Near the close of the Roman Empire, Blue Lotus was being traded to the far corners of the known world, from Brittania to India. The lotus even features prominently in Mayan religious art, costumes, and ceremonies.

The blue lotus flower (Nymphea caerulea) is an Egyptian water lily containing apomorphine and nuciferine. Apomorphine has been described as a psychoactive alkaloid and is a non- selective dopamine agonist primarily used to treat Parkinson’s disease as it stimulates dopamine receptors and improves motor function.

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White Lily

White Lotus is frequently depicted within Egyptian art in the form of stone carvings and paintings. It’s clear that this ancient culture highly revered both of these plant species, likely due to their fascinating psychoactive effects. These images often involve scenes of parties, dancing, and rituals.

White Lotus or White Waterlily (Nymphaea alba) contains the psychoactive compounds nupharine and nymphaeine, which have euphoric, sedative and narcotic effects. According to some sources, waterlily is also a potent aphrodisiac.

White Lily native to Mexico and Central and South America dates back to the time of Mayan’s. It generates feelings of floating and euphoric sensations.

Red Lily

Red Lotus (Nymphaea rubra) belongs to the Mymphaceae family and is known to be originated in India, Nile Delta, and Thailand. Its leaves are heterophyllus and they have different appearances under the water surface and above the water surface. This plant is common in the ponds and shallow lakes throughout tropical and temperate Asia; Indonesia, Malaysia, Vietnam, Myanmar, Thailand, Laos, Cambodia, Philippines, Taiwan, Yunnan, Sri Lanka, India, and Bangladesh. Its leaves have hairy or fuzzy undersides and stems are also covered by the hairs. It produces perennial and erect rootstocks and rhizomes that help anchorage in the muddy bottom.

It is a well-known herb for peace-stimulating and relaxing properties and thereby brings a sense of euphoria and wellbeing. It produces good sedative effects and helps consumers to sleep better. It is being used as an aphrodisiac since ancient times.

Research has shown that the red lotus contains both nuciferine, and aporphine. Aporphine is a psychoactive alkaloid and is a specific dopamine agonist for the treatment of alcohol addiction, opiates, Alzheimer’s disease, erectile dysfunctioning, and Parkinson’s disease. This compound causes stimulation of euphoric, uplifted, and happy feelings. While nuciferine is a specific alkaloid having an association with dopamine receptors. Research findings have shown that red lotus is significantly helpful to promote health and wellness due to its antioxidant, anthelmintic, anti-diabetic, and immunomodulatory properties. Red lily is reported to have excellent immunomodulating activities and the polysaccharides produced in the carpels of its flowers antitumor activities by activation of macrophages and naturally killing the cells by receptor binding.


„Historically, kanna forms part of the traditional practices of South Africa’s first people, Khoisan,“ says clinical psychologist Vincenzo Sinisi, SAPA, HPCSA, founder of Therapy Route.“The Khoisan populated parts of what is now South Africa even before the African people considered indigenous to the region today did.“

It was typically consumed as a pinch of ground-up fermented plant matter and held under the tongue or chewed before swallowing. Today, extracts, tea, and supplements are available for easier ingestion.

The Western world, and its mental health professionals in particular, are taking an interest in kanna thanks to its calming and mind-clearing properties, which can work wonders for people dealing with anxiety and depression.

In the brain, kanna naturally bolsters serotonin reuptake and strengthens the mechanisms of attention and memory, effectively reducing stress, boosting mood, and promoting cognitive function.

Kanna contains, in addition to many other less important, two main active substances – mesembrine and mesembrenone (also delta-7-mesembrenone, which is formed during the fermentation of the plant, does not differ significantly from mesembrenone in the nature of the effects). These alkaloids have several mechanisms of action on our nervous system. The resulting effect of the extract will then depend on the predominance of one or the other alkaloid.


Mesembrine acts primarily as an effective SRI (the mechanism of action is similar to that of SSRIs, in addition to serotonin it also affects other neurotransmitters) – it increases the amount of serotonin in synapses and acts in a similar way as current antidepressants. In recent years, this antidepressant effect of kanna has been shown to be more effective (immediate, and without side effects) than commonly available synthetic antidepressants. Kanna could replace these drugs in the treatment of a variety of neurotic disorders.
A relatively new finding is the fact that mesembrine stimulates the activity of the VMAT-2 protein, which is a relatively unique mechanism among psychoactive substances. It supports an increase in levels of neurotransmitters in synapses – especially dopamine, which in combination with other mechanisms probably explains the stimulating, euphoric, even empathogenic effects and the possibility of recreational use of kanna as an alternative to MDMA (which is most evident when mesembrine extract is used nasally). In a clinical setting, this effect could be potentially therapeutic for dopamine deficiency disorders – Parkinson’s disease, ADHD and others.


Mesembrenone also acts as an SRI, but its primary action is as an inhibitor of the enzyme phosphodiesterase 4. PDEA4 inhibition improves intracellular communication in the brain, resulting in nootropic, neuroprotective and anti-inflammatory effects. PDEA4 inhibitors are currently being studied as potential agents for the treatment of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, but also many inflammatory diseases.


Found on all continents throughout the world, Acacia trees, used by Noah to build the ark, are revered in cultures dating back centuries because some varieties contain the psychedelic substance dimethyltryptamine (DMT), phenethylamine as well as methylenedioxyphenethylamines. The Tree of Knowledge in the Garden of Eden offered something far more tempting than an apple. It is thought that the burning bush that Moses encountered on the mountain was the acacia.

Certain varieties of the acacia contain Phenethylamine as well as methylenedioxyphenethylamines which are used as empathogens, stimulants, psychedelics and/or antidepressants. Methylenedioxyphenethylamines are used to formulate MDMA which is used in sacred medicine circles and for PTSD and Trauma Therapy.


Sassafras is the primary ingredient in traditional root beer. Sassafras tree (Sassafras albidum) is a very common native plant in the Eastern United States. It is often seen in clumps of weedy saplings, but as sassafrases mature they can grow to be large trees. There are lots of controversies and conspiracy theories relating to Sassafras and its active compound safrole. Sassafras is an ancient healing plant for eastern native american tribes. It is also the characteristic flavoring of traditional root beer.

The safrole in sassafras can be used to make the sassafras compound MDA which is the active psychedelic compound used in plant medicine.


Passionflower is a climbing vine that is native to the southeastern United States and Central and South America.

Native peoples of the Americas used passionflower as a sedative. Sixteenth-century Spanish explorers in South America learned of passionflower. The plant was then brought to Europe, where it became widely cultivated and was introduced to European folk medicine.

Used to help to reduce nonspecific anxiety and anxiety. Also can be used to attention-deficit hyperactivity disorder, congestive heart failure, insomnia, and stress.

Green Tea

Camellia sinensis is the source of Green Tea. Originally used and grown in China.

An amino acid in green tea L-Theanine is known for various properties that stimulates focus and increase serotonin and dopamine while reducing cortisol.

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